Bolognese have secured their first win at the hands of Juventus in four matches with a 2-0 victory at the Stadio San Paolo.
Bologna have now won seven of their past eight games at the Allianz Arena.
The win was the first time Genoa had conceded two goals in a Serie A game since a 1-0 defeat by Udinese on November 9.
It was Juve’s fifth consecutive victory at San Paoli and sixth straight away victory over the Gioiares, who have won five of their last six games in the competition.
The Giallorossi had gone ahead at half-time after a superb second-half goal by Gianluca Pisanu put his side ahead.
But the hosts went close to equalising with a penalty after Massimo Gavazzi’s shot was tipped over by goalkeeper Federico Gennaro.
The visitors had looked to be in control early in the second half, but a superb save from Genoa’s Marco Vittori saved Antonio Candreva’s effort.
Gianluca was brought down by a defender and he was sent off for a foul on Pisanuso.
Gennaro was also booked in the closing stages, while Genoa goalkeeper Pazzini was sent to the stands after making an unsporting challenge on Candrevas.